WebcMaf is a transcription factor with basic leucine zipper domains that mediate DNA binding to the cMaf recognition element (8,9). cMaf is expressed in monocyte and macrophage … WebcMaf is a transcription factor with basic leucine zipper domains that mediate DNA binding to the cMaf recognition element (8,9). cMaf is expressed in monocyte and macrophage lineages, as well as in T cell subsets (10,11). Studies of trans-genic cMaf T helper (Th) cells revealed that cMaf is important
Soluble adenylyl cyclase contributes to imiquimod-mediated
WebNov 16, 1998 · The c-maf protooncogene is a T helper cell type 2 (Th2)-specific transcription factor that activates the interleukin (IL)-4 promoter in vitro. Although it has been postulated that c-maf directs the Th2-specific expression of the IL-4 gene in vivo, direct evidence that c-maf functions during the differentiation of normal, primary T cells is … WebApr 27, 2024 · The transcription factor c-Maf, belonging to the AP-1 family of basic region/leucine zipper factor, is highly expressed by mature Tfh cells, and is thought to … korean marinated beef
The Transcription Factor c-Maf Controls the Production of Interleukin …
WebInterestingly, loss of sAC did not impact the expression of Th17 lineage-defining transcription factors (such as Rorc and cMaf) but rather was required for CREB-dependent gene expression, which is known to support Th17 cell gene expression. Finally, topical application of small molecule sAC inhibitors (sACi) reduced imiquimod-induced ... WebHere, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer. c-Maf … WebWhile regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment factor essential to all Tγδ17 cells has remained undefined. In this study, we … manglesdorf parole hearing